Amino Acid Transporters in the Human Placenta
نویسندگان
چکیده
منابع مشابه
Expression and functional characterisation of System L amino acid transporters in the human term placenta
BACKGROUND System L transporters LAT1 (SLC7A5) and LAT2 (SLC7A8) mediate the uptake of large, neutral amino acids in the human placenta. Many System L substrates are essential amino acids, thus representing crucial nutrients for the growing fetus. Both LAT isoforms are expressed in the human placenta, but the relative contribution of LAT1 and LAT2 to placental System L transport and their subce...
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We have investigated L-arginine transport systems in the human placental syncytiotrophoblast across gestation using purified microvillous (MVM) and basal (BM) plasma membrane vesicles. In MVM from first-trimester and term placentas, L-arginine transport was by systems y(+) and y(+)L. In BM (term placentas), however, there was evidence for system y(+)L only. The Michaelis constant of system y(+)...
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Abnormal fetal growth, which is associated with both perinatal morbidity as well as metabolic diseases in adulthood, is an important clinical problem affecting as many as 15% of all pregnancies. However, to this date, there is no specific treatment of this condition. Fetal growth is intimately linked to the nutrient transport functions of the placenta and placental amino acid transporter activi...
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There is no knowledge of the transport mechanisms by which solutes cross the cat placenta or any other endotheliochorial placenta. Here, we investigated whether the amino acid transport systems beta and A are present in the cat placenta using a placental fragment uptake technique. Data were compared with studies in the human placenta, in which the presence of these two transport systems has bee...
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E. E. Champion, S. J. Mann, J. D. Glazier, C. J. P. Jones, J. M. Rawlings, C. P. Sibley, and S. L. Greenwood Academic Unit of Child Health, University of Manchester, St. Mary’s Hospital, Manchester, M13 OJH; Waltham Centre for Pet Nutrition, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT; and Academic Unit of Obstetrics and Gynaecology, University of Manchester, St. Mary’s Hospi...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2001
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-200102000-00003